PerspectiveImmunology

An Antibody Paradox, Resolved

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Science  31 Mar 2006:
Vol. 311, Issue 5769, pp. 1875-1876
DOI: 10.1126/science.1126030

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Summary

The immune effect of a cytokine bound to an antibody is paradoxically much stronger than that of the cytokine alone, suggesting a way to lower therapeutic doses and thereby reduce side effects.