Technical Comments

Comment on "PDK1 Nucleates T Cell Receptor-Induced Signaling Complex for NF-κB Activation"

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Science  07 Apr 2006:
Vol. 312, Issue 5770, pp. 55
DOI: 10.1126/science.1122000

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We observe that protein kinase C θ (PKCθ) is phosphorylated on the activation loop at threonine 538 (Thr-538) before T cell activation. Our results are inconsistent with the conclusions of Lee et al. (Reports, 1 April 2005, p. 114) that the Thr-538 phosphorylation of PKCθ is regulated by T cell receptor activation. Other mechanisms, such as autophosphorylation of Thr-219, might orchestrate the cellular function of PKCθ in T cells.

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