Technical Comments

Response to Comment on "PDK1 Nucleates T Cell Receptor-Induced Signaling Complex for NF-κB Activation"

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Science  07 Apr 2006:
Vol. 312, Issue 5770, pp. 55
DOI: 10.1126/science.1115362

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In their comment, Gruber et al. report constitutive phosphorylation of protein kinase C θ at threonine residue 538. However, they fail to note that, consistent with our results, a number of other groups have previously reported inducible phosphorylation of Thr-538 in T cells. Although the physiological relevance of this discrepancy is unclear, substantial differences in experimental conditions and reagents may account for the conflicting observations.

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