RESOURCES: The Word on the Worm

Science  14 Apr 2006:
Vol. 312, Issue 5771, pp. 169e
DOI: 10.1126/science.312.5771.169e

High school students and cell biologists alike have consulted WormBook to learn about Caenorhabditis elegans and methods for studying it. The year-old reference serves as a companion for the genomics storehouse WormBase and provides almost 90 peer-reviewed chapters, all written by wormologists, on different aspects of nematode biology. Page through the molecular biology section to learn how the animals fix broken DNA, or visit the evolution and ecology chapters to meet some of the pathogens that make life miserable for worms. Beginners will find tips on basic procedures such as how to stain the slippery creatures to delineate cellular structures. The cool blue spots freckling a nematode, for example, are cell nuclei tagged with DAPI, a compound that clings to DNA. Lab veterans can bone up on more advanced techniques such as how to shut down genes.

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