RNA Interference with Viruses

Science  21 Apr 2006:
Vol. 312, Issue 5772, pp. 333
DOI: 10.1126/science.312.5772.333o

RNA interference (RNAi) plays a role in the defense against viral infection in plants, but does it play a similar role in animals? The evidence from tissue culture cells and Caenorhabditis elegans-based systems has suggested that this is so, but definitive evidence in a system that uses endogenous viruses and whole animals has been lacking. Wang et al. (p. 452, published online 23 March) now show that both Drosophila embryos and adult flies mount a substantial innate immune response to insect viruses that requires the RNAi machinery, and that this innate defense is separable from the innate bacterial defense provided by the Toll and immune-deficiency pathways.

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