CELL BIOLOGY: What Comes In Must Get Out

Science  21 Apr 2006:
Vol. 312, Issue 5772, pp. 339a
DOI: 10.1126/science.312.5772.339a

Certain bacterial toxins, viruses, and proteins enter cells by an atypical form of endocytosis mediated by caveolae, which are cholesterol- and glycolipid-rich membrane invaginations particularly prevalent on the endothelial cells that line blood vessels. The mechanisms involved in caveolar uptake are not well understood. Choudhury et al. find that syntaxin 6, a protein known to be involved in membrane fusion events in the secretory pathway, is required. It seems that syntaxin 6 is involved in the recycling and delivery of caveolar components, such as caveolin, GM1 ganglioside, and glycosylphosphatidylinositol-linked proteins, to the cell surface via the Golgi complex. A key factor in the process may be ganglioside trafficking; the addition of GM1 ganglioside to cells with inhibited syntaxin 6 restored caveolin delivery to the cell surface, and caveolar endocytosis. — SMH

Nature Cell Biol. 8, 317 (2006)

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