DATABASES: Protein Geography

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Science  21 Apr 2006:
Vol. 312, Issue 5772, pp. 343
DOI: 10.1126/science.312.5772.343b

The heart and the eye depend on different lineups of proteins, and so do a mitochondrion and a lysosome. But scientists haven't compiled a comprehensive list of the proteins residing in each type of organ and organelle. Two databases announced earlier this month in Cell take a step in that direction. Using mass spectrometry and other techniques, researchers with the Mouse Proteome Project* at the University of Toronto in Canada pinpointed more than 3200 proteins in six organs. The project's database indicates whether each protein is present in four cellular compartments, such as the cytoplasm and mitochondria. The Organelle Map Database from the Max Planck Institute for Biochemistry in Martinsried, Germany, focuses on the mouse liver and caches results from a method called protein correlation profiling. The site maps some 1400 proteins to 10 cellular locations.

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