PerspectivePharmacology

Hitting the Hot Spots of Cell Signaling Cascades

Science  21 Apr 2006:
Vol. 312, Issue 5772, pp. 377-378
DOI: 10.1126/science.1126903

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Summary

Small-molecule inhibitors can bind in several different ways to protein interaction sites on signaling proteins, thereby selecting downstream pathways. This type of targeting may be useful therapeutically.