Technical Comments

Response to Comment on “Evidence for Positive Epistasis in HIV-1”

Science  12 May 2006:
Vol. 312, Issue 5775, pp. 848c
DOI: 10.1126/science.1110994

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Wang et al. analyzed artificially biased data to show that our results can be explained by a bias against sequences with low fitness. We explicitly acknowledged this potential caveat in our original study. Showing that an artificially introduced bias can produce a spurious signal of positive epistasis does not demonstrate that such bias exists in our original data.

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