Regulating Energy Balance: The Substrate Strikes Back

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Science  12 May 2006:
Vol. 312, Issue 5775, pp. 861-864
DOI: 10.1126/science.1127971

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Hormones and dietary nutrients control appetite and metabolism by acting on the brain, where the signals they elicit promote hunger or satiety. Neurons in the hypothalamus integrate these signals to regulate energy balance.