News of the WeekMolecular Biology

RNAi Safety Comes Under Scrutiny

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Science  26 May 2006:
Vol. 312, Issue 5777, pp. 1121
DOI: 10.1126/science.312.5777.1121a

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What began as an effort to craft a better hepatitis therapy using a strategy called RNA interference has ended in the deaths of dozens upon dozens of mice--a harsh safety alarm for biomedical researchers looking to RNAi as a treatment for HIV, cancer, neurodegenerative diseases, and more. (Read more.)