PerspectiveTRANSCRIPTION

Gene Expression Needs a Break to Unwind Before Carrying On

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Science  23 Jun 2006:
Vol. 312, Issue 5781, pp. 1752-1753
DOI: 10.1126/science.1129808

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Summary

The molecular events that change a quiescent gene within compacted chromatin into one actively transcribing RNA are not yet clear. Unexpectedly, enzymes that create and repair DNA breaks seem to be necessary.