TOOLS: Notching Connections

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Science  30 Jun 2006:
Vol. 312, Issue 5782, pp. 1851
DOI: 10.1126/science.312.5782.1851e

In animals from nematodes to humans, the Notch pathway helps tender young cells decide whether they'll grow up into a neuron or another type of cell. Researchers can trace the molecular liaisons that make up the mammalian version of the pathway at the Murine Notch Signal Transduction Database, created by grad student Julius Barsi and undergraduate Zack Mahdavi of the University of Texas, Austin. To uncover information about particular components, mouse across a map of the pathway and click on a protein, gene, or RNA molecule. Up pops a page that lists the other components your choice links to and describes these interactions. Entries also furnish PubMed abstracts for papers that provide evidence for each connection.

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