PerspectiveCell Biology

Stressed Cells Cope with Protein Overload

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Science  07 Jul 2006:
Vol. 313, Issue 5783, pp. 52-53
DOI: 10.1126/science.1130469

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Summary

Stress on eukaryotic cells causes build-up of unfolded proteins in the endoplasmic reticulum. To protect itself, the cell degrades mRNA for ER proteins.