DATABASE: GPS for Proteins

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Science  14 Jul 2006:
Vol. 313, Issue 5784, pp. 151
DOI: 10.1126/science.313.5784.151e

Where a protein hangs out and how it interacts with the cell's membranes furnish clues to its function. At LOCATE, researchers can track down both types of information for a standard set of more than 33,000 mouse proteins. To pinpoint molecules, computational cell biologist Rohan Teasdale of the University of Queensland in St. Lucia, Australia, and colleagues drew on their own experiments and data from the literature. Click on a cell map to find out which proteins congregate in the nucleus, mitochondria, and other organelles. The site also classifies proteins according to their relationship to cell and organelle membranes, such as whether they pass through a membrane once or snake through several times.

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