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Response to Comment on “Ongoing Adaptive Evolution of ASPM, a Brain Size Determinant in Homo sapiens” and “Microcephalin, a Gene Regulating Brain Size, Continues to Evolve Adaptively in Humans”

Science  14 Jul 2006:
Vol. 313, Issue 5784, pp. 172b
DOI: 10.1126/science.1122822

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Currat et al. present computer simulations to argue that the haplotype structure found at the microcephalin and ASPM genes can be better explained by demographic history rather than by selection. The demographic models they adopt, however, strongly contradict a decade of empirical research on human demographic history and do not account for the critical features of the data on which our argument for selection was based.

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