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Structure of the Vesicular Stomatitis Virus Nucleoprotein-RNA Complex

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Science  21 Jul 2006:
Vol. 313, Issue 5785, pp. 357-360
DOI: 10.1126/science.1126953

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Abstract

Vesicular stomatitis virus is a negative-stranded RNA virus. Its nucleoprotein (N) binds the viral genomic RNA and is involved in multiple functions including transcription, replication, and assembly. We have determined a 2.9 angstrom structure of a complex containing 10 molecules of the N protein and 90 bases of RNA. The RNA is tightly sequestered in a cavity at the interface between two lobes of the N protein. This serves to protect the RNA in the absence of polynucleotide synthesis. For the RNA to be accessed, some conformational change in the N protein should be necessary.

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