Activated Signal Transduction Kinases Frequently Occupy Target Genes

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Science  28 Jul 2006:
Vol. 313, Issue 5786, pp. 533-536
DOI: 10.1126/science.1127677

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Cellular signal transduction pathways modify gene expression programs in response to changes in the environment, but the mechanisms by which these pathways regulate populations of genes under their control are not entirely understood. We present evidence that most mitogen-activated protein kinases and protein kinase A subunits become physically associated with the genes that they regulate in the yeast (Saccharomyces cerevisiae) genome. The ability to detect this interaction of signaling kinases with target genes can be used to more precisely and comprehensively map the regulatory circuitry that eukaryotic cells use to respond to their environment.

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