Fibrin Fibers Have Extraordinary Extensibility and Elasticity

See allHide authors and affiliations

Science  04 Aug 2006:
Vol. 313, Issue 5787, pp. 634
DOI: 10.1126/science.1127317

You are currently viewing the abstract.

View Full Text


Blood clots perform an essential mechanical task, yet the mechanical behavior of fibrin fibers, which form the structural framework of a clot, is largely unknown. By using combined atomic force‐fluorescence microscopy, we determined the elastic limit and extensibility of individual fibers. Fibrin fibers can be strained 180% (2.8-fold extension) without sustaining permanent lengthening, and they can be strained up to 525% (average 330%) before rupturing. This is the largest extensibility observed for protein fibers. The data imply that fibrin monomers must be able to undergo sizeable, reversible structural changes and that deformations in clots can be accommodated by individual fiber stretching.

    View Full Text