Technical Comments

Response to Comment on “Cell Type Regulates Selective Segregation of Mouse Chromosome 7 DNA Strands in Mitosis”

Science  25 Aug 2006:
Vol. 313, Issue 5790, pp. 1045c
DOI: 10.1126/science.1128552

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To explain how all chromosome recombinants can become homozygous for a marker located distal to the crossover point, we proposed that mitotic recombination must be restricted to two specific chromatids and that the selective chromatid segregation process follows recombination. We refute Haber's contention that our results can be explained by the conventional X-segregation process if recombination of all possible combinations of chromatids is considered.

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