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Response to Comment on "Transitions to Asexuality Result in Excess Amino Acid Substitutions"

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Science  08 Sep 2006:
Vol. 313, Issue 5792, pp. 1389
DOI: 10.1126/science.1128745

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Asexual populations experience a reduction in the efficiency of selection when compared with sexual populations. Because asexual lineages of Daphnia pulex exhibit no consistent change in mitochondrial base-composition bias, Butlin suggests that this bias is not maintained by selection. On the basis of frequencies of polymorphic directional base changes, we suggest that it predominantly reflects mutation bias.

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