Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria

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Science  08 Sep 2006:
Vol. 313, Issue 5792, pp. 1438-1441
DOI: 10.1126/science.1129577

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Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load.

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