Report

Gene Transposition as a Cause of Hybrid Sterility in Drosophila

See allHide authors and affiliations

Science  08 Sep 2006:
Vol. 313, Issue 5792, pp. 1448-1450
DOI: 10.1126/science.1128721

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

We describe reproductive isolation caused by a gene transposition. In certain Drosophila melanogasterD. simulans hybrids, hybrid male sterility is caused by the lack of a single-copy gene essential for male fertility, JYAlpha. This gene is located on the fourth chromosome of D. melanogaster but on the third chromosome of D. simulans. Genomic and molecular analyses show that JYAlpha transposed to the third chromosome during the evolutionary history of the D. simulans lineage. Because of this transposition, a fraction of hybrids completely lack JYAlpha and are sterile, representing reproductive isolation without sequence evolution.

View Full Text