Technical Comments

Comment on "Large-Scale Sequence Analysis of Avian Influenza Isolates"

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Science  15 Sep 2006:
Vol. 313, Issue 5793, pp. 1573
DOI: 10.1126/science.1131729

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Obenauer et al. (Research Articles, 17 March 2006, p. 1576) reported that the influenza A virus PB1-F2 gene is evolving under strong positive selection, as documented by an extremely high ratio of the number of nonsynonymous nucleotide substitutions to the number of synonymous substitutions (dN/dS). However, we show that this observation is likely to be an artifact related to the location of PB1-F2 in the +1 reading frame of the PB1 gene.

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