Technical Comments

Response to Comment on "Large-Scale Sequence Analysis of Avian Influenza Isolates"

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Science  15 Sep 2006:
Vol. 313, Issue 5793, pp. 1573
DOI: 10.1126/science.1131840

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We repeated the dN/dS analysis as described by Holmes et al. using the methods and data as described in our original report. We obtained essentially the same results and agree that it cannot be concluded from dN/dS calculations whether PB1-F2 is under positive, negative, or neutral selection.

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