Vesicle Formation at the Plasma Membrane and Trans-Golgi Network: The Same but Different

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Science  15 Sep 2006:
Vol. 313, Issue 5793, pp. 1591-1594
DOI: 10.1126/science.1118133

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An elaborate vesicle transport system supports the active exchange of membranes and protein cargo between the plasma membrane and the trans-Golgi network. Many observations suggest that highly conserved mechanisms are used in vesicle formation and scission. Such similarity is found both at the level of the receptor-ligand sequestration process that uses clathrin and associated polymeric and monomeric adaptor proteins, and in the machinery used to deform and vesiculate lipid membranes.

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