DATABASE: Proteins at Home

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Science  29 Sep 2006:
Vol. 313, Issue 5795, pp. 1861
DOI: 10.1126/science.313.5795.1861a

The protein Nsp1 forms part of the nuclear pore, the channel that passes through a cell's nuclear membrane. The molecule usually hangs out at the rim of the nucleus. Track down Nsp1 and more than 30,000 other proteins with Organelle DB, started by molecular biologist Anuj Kumar of the University of Michigan, Ann Arbor. You can search protein localization data for 138 species, including lab stalwarts such as Drosophila and Caenorhabditis elegans and more exotic creatures such as the pygmy chimp Pan paniscus. Using information from the Kumar lab's experiments, the literature, and other databases, the site narrows each protein's whereabouts among more than 50 organelles and other cellular locales. Launch the new Organelle View feature to map your favorite yeast proteins on a three-dimensional cell model.

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