Research Article

The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

Science  29 Sep 2006:
Vol. 313, Issue 5795, pp. 1929-1935
DOI: 10.1126/science.1132939

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Abstract

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this “Connectivity Map” resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

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