Research Article

The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

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Science  29 Sep 2006:
Vol. 313, Issue 5795, pp. 1929-1935
DOI: 10.1126/science.1132939

Article Information

vol. 313 no. 5795 1929-1935

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History: 
  • Received for publication July 24, 2006
  • Accepted for publication September 6, 2006

Author Information

  1. Justin Lamb1,*,
  2. Emily D. Crawford1,,
  3. David Peck1,
  4. Joshua W. Modell1,
  5. Irene C. Blat1,
  6. Matthew J. Wrobel1,
  7. Jim Lerner1,
  8. Jean-Philippe Brunet1,
  9. Aravind Subramanian1,
  10. Kenneth N. Ross1,
  11. Michael Reich1,
  12. Haley Hieronymus1,2,
  13. Guo Wei1,2,
  14. Scott A. Armstrong2,3,
  15. Stephen J. Haggarty1,4,
  16. Paul A. Clemons1,
  17. Ru Wei1,
  18. Steven A. Carr1,
  19. Eric S. Lander1,5,6,
  20. Todd R. Golub1,2,3,5,7,*
  1. 1 Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
  2. 2 Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  3. 3 Department of Medicine, Children's Hospital Boston, Boston, MA 02115, USA.
  4. 4 Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02144, USA.
  5. 5 Harvard Medical School, Boston, MA 02115, USA.
  6. 6 Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  7. 7 Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
  1. * To whom correspondence should be addressed. E-mail: golub{at}broad.harvard.edu, justin{at}broad.mit.edu
  • Present address: University of California, San Francisco, CA 94158, USA.

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