Research Article

The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

See allHide authors and affiliations

Science  29 Sep 2006:
Vol. 313, Issue 5795, pp. 1929-1935
DOI: 10.1126/science.1132939

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. eLetters are not edited, proofread, or indexed.  Please read our Terms of Service before submitting your own eLetter.

Compose eLetter

Plain text

  • Plain text
    No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests
CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Image CAPTCHA
Enter the characters shown in the image.

Vertical Tabs

  • Re: Response to E-Letter by Golub

    Dr. Golub’s response to my criticism of their paper does not clarify the central issue that I raised — that their paper is biased in favor of establishing the usefulness of a connectivity map for revealing connections among small molecules, genes, and diseases by generating gene-expression signatures. I mentioned antiepileptic drugs only as an example to show how the authors have selectively presented, discussed, and highlighte...

    Show More
    Competing Interests: None declared.
  • The Connectivity Map is Biased Towards Experimental Approach

    The Research Article “The connectivity map: using gene expression signatures to connect small molecules, genes, and disease” (29 Sept. 2006, p. 1929) by J. Lamb et al. (1) used a global gene expression method to construct a connectivity map for revealing connections among small molecules, genes, and diseases. Lamb et al. used DNA microarray “as the universal language with which to describe cellular re...

    Show More
    Competing Interests: None declared.
  • Response to E-Letter by Sharma

    We thank Dr. Sharma for his thoughtful comments on our Connectivity Map paper. We offer the following response.

    Regarding the connections between valproic acid and HDAC inhibitors, Dr. Sharma appears to be missing the basic premise of the Connectivity Map approach. The method does not identify global similarities between perturbations (drug treatments), but rather it identifies similarities with respect to a que...

    Show More
    Competing Interests: None declared.
  • Bias in Favor of Connectivity Map

    The Research Article “The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease” (29 Sept. 2006, p. 1929) by J. Lamb et al.’ (1) is biased in favor of establishing the usefulness of a connectivity map for revealing connections among small molecules, genes, and diseases by generating gene-expression signatures. For example, among the three antiepileptic drugs initially chosen for...

    Show More
    Competing Interests: None declared.