PerspectiveCell Signaling

The Double Life of a Transcription Factor Takes It Outside the Nucleus

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Science  06 Oct 2006:
Vol. 314, Issue 5796, pp. 64-65
DOI: 10.1126/science.1133757

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Although transcription factors had been thought to act only in the nucleus, new evidence that they can regulate calcium channels in the cytoplasm represents a mechanism for two-way communication within cells.