DATABASE: Ready, Set, Read

Science  13 Oct 2006:
Vol. 314, Issue 5797, pp. 229c
DOI: 10.1126/science.314.5797.229c

You'd be lost if you opened a mystery novel at chapter 5 instead of chapter 1. But cells don't always start at the beginning when they copy a gene into RNA. A gene can contain multiple start sites, or promoters, and which one a cell chooses can change in diseases such as cancer. For a list of these initiation sequences, check out the Eukaryotic Promoter Database, hosted by the Swiss Institute for Bioinformatics in Lausanne. The site compiles experimentally verified promoters from a host of species, including humans, nematodes, fruit flies, and cattle. Users can browse the entries or compare them to their own sequences.

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