EDUCATION: Mix-and-Match Chemistry

Science  27 Oct 2006:
Vol. 314, Issue 5799, pp. 571b
DOI: 10.1126/science.314.5799.571b

Instead of synthesizing and testing compounds one at time, drug designers now often create lineups of slightly varying molecules for faster evaluation, a method called combinatorial chemistry. To unlock the secrets of this approach to drug discovery, browse this primer from Oleg Larin of the Moscow State Academy of Fine Chemical Technology in Russia. The site's six brief chapters explore how researchers perform combinatorial chemistry in the solid phase and in solution. Readers can delve into the different resins for cradling molecules and compare various tags for tracking synthesis products. The site also features a glossary and a collection of combinatorial chemistry articles.

http://www.combichemistry.com/

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