Alzheimer's Disease After 100 Years

Science  03 Nov 2006:
Vol. 314, Issue 5800, pp. 721a
DOI: 10.1126/science.314.5800.721a
CREDIT: UNIVERSITY CLINIC OF TÜBINGEN

In Tübingen, Germany, on 3 November 1906, Alois Alzheimer described the first documented case of Alzheimer's disease, a neurodegenerative disorder that impairs memory, cognition, and behavior (see the cover). Goedert and Spillantini (p. 777) review what is known about the molecular pathology of the disease, which is defined by the presence within the brain of amyloid-β-rich plaques and tau-containing neurofibrillary tangles. Roberson and Mucke (p. 781) review the prospects for therapy to help delay or prevent pathological processes within the brains of afflicted individuals, in order to prolong patients' cognitive abilities, and maintain for as long as possible their quality of life.

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