Technical Comments

Response to Comment on Chong et al. on Diabetes Reversal in NOD Mice

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Science  24 Nov 2006:
Vol. 314, Issue 5803, pp. 1243
DOI: 10.1126/science.1129918

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Abstract

We failed to detect transdifferentiation of spleen cells into β cells following diabetes reversal in nonobese diabetic (NOD) mice, thus contradicting a key finding of a 2003 report. We respond to Faustman et al. by justifying the use of mouse insulin promoter–green fluorescent protein transgenic mice as an appropriate system for detecting spleen-derived β cells in the islets of cured NOD mice.

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