Technical Comments

Response to Comment on Nishio et al. on Diabetes Reversal in NOD Mice

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Science  24 Nov 2006:
Vol. 314, Issue 5803, pp. 1243
DOI: 10.1126/science.1129919

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Contrary to previous findings, we found no significant differentiation of splenocytes into pancreatic islet cells in nonobese diabetic (NOD) mice treated with an immune adjuvant and allogenic spleen cells. We show that our single-nucleotide polymorphism assay has the requisite sensitivity to support our contention. The experiments of Faustman et al. lack adequate controls, and we maintain that no evidence of islet regeneration has been presented.

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