Left-Right Dynein Motor Implicated in Selective Chromatid Segregation in Mouse Cells

See allHide authors and affiliations

Science  05 Jan 2007:
Vol. 315, Issue 5808, pp. 100-101
DOI: 10.1126/science.1129429

You are currently viewing the abstract.

View Full Text


During cell division, copies of mouse chromosome 7 are segregated selectively or randomly to daughter cells depending on the cell type. The mechanism for differential segregation is unknown. Because mouse left-right dynein (LRD) gene mutations result in randomization of visceral organs' laterality, we hypothesized that LRD may also function in selective chromatid segregation. Indeed, upon knock-down by RNA interference methods, LRD depletion disrupts biased segregation. LRD messenger RNA presence or absence correlates with the observed segregation patterns. This work supports the claim that LRD functions in a mechanism for selective chromatid segregation.

    View Full Text