Technical Comments

Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"

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Science  12 Jan 2007:
Vol. 315, Issue 5809, pp. 187
DOI: 10.1126/science.1129402

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Herbert et al. (Reports, 14 April 2006, p. 279) reported an association between the INSIG2 gene variant rs7566605 and obesity in four sample populations, under a recessive model. We attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity.

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