Technical Comments

Response to Comments on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"

See allHide authors and affiliations

Science  12 Jan 2007:
Vol. 315, Issue 5809, pp. 187
DOI: 10.1126/science.1129763

You are currently viewing the abstract.

View Full Text


Identification of genetic variants affecting complex traits such as obesity is confounded by many types of bias, especially when effect sizes are small. Given our findings of a positive association between rs7566605 and body mass index in four out of five separate samples, a false positive finding cannot be ruled out with certainty but seems unlikely. Meta-analyses of multiple large studies will help refine the estimate of the effects of rs7566605 on body mass index.

View Full Text