Technical Comments

Response to Comments on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"

Science  12 Jan 2007:
Vol. 315, Issue 5809, pp. 187
DOI: 10.1126/science.1129763

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Identification of genetic variants affecting complex traits such as obesity is confounded by many types of bias, especially when effect sizes are small. Given our findings of a positive association between rs7566605 and body mass index in four out of five separate samples, a false positive finding cannot be ruled out with certainty but seems unlikely. Meta-analyses of multiple large studies will help refine the estimate of the effects of rs7566605 on body mass index.

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