Prokaryotic DNA Segregation

Science  02 Mar 2007:
Vol. 315, Issue 5816, pp. 1189h
DOI: 10.1126/science.315.5816.1189h

The prokaryotic actin-like protein ParM is dynamically unstable and is thought to play a role in DNA segregation. Garner et al. (p. 1270) describe the complete reconstitution of DNA segregation in vitro using purified components. ParM, together with DNA and a DNA-binding protein, generate a bipolar spindle that can promote the directional movement of DNA and can explain in vivo DNA movements. Thus, a dynamic filament protein can mediate DNA movement in prokaryotes.

Related Content

Navigate This Article