The Heart of Metabolic Syndrome?

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Science  02 Mar 2007:
Vol. 315, Issue 5816, pp. 1189j
DOI: 10.1126/science.315.5816.1189j

Patients with coronary artery disease (CAD) often have accompanying hypertension, diabetes, and aberrant levels of cholesterol and triglycerides. This diverse group of risk factors is collectively known as “metabolic syndrome,” but the underlying molecular mechanisms that link these disorders are still poorly understood. Mani et al. (p. 1278), have now identified the causative mutation in a family afflicted with a rare, inherited form of early-onset CAD that cosegregates with many features of metabolic syndrome. The culprit gene encodes low-density lipoprotein receptor-related protein 6 (LRP6), a co-receptor in the Wnt cellular signaling pathway.

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