Variation on Synaptic Potentiation

Science  02 Mar 2007:
Vol. 315, Issue 5816, pp. 1189m
DOI: 10.1126/science.315.5816.1189m

Synaptic changes linked to associative learning are well known. Lamsa et al. (p. 1262) examined long-term synaptic plasticity in different types of interneurons in rat hippocampal slices. They discovered an induction rule for long-term potentiation (LTP) that shows unusual characteristics. In contrast to known forms of plasticity, pairing synaptic input with hyperpolarization resulted in LTP, whereas pairing it with depolarization prevented it.

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