Temporal Frequency of Subthreshold Oscillations Scales with Entorhinal Grid Cell Field Spacing

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Science  23 Mar 2007:
Vol. 315, Issue 5819, pp. 1719-1722
DOI: 10.1126/science.1139207

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Grid cells in layer II of rat entorhinal cortex fire to spatial locations in a repeating hexagonal grid, with smaller spacing between grid fields for neurons inmore dorsal anatomical locations. Data from in vitro whole-cell patch recordings showed differences in frequency of subthreshold membrane potential oscillations in entorhinal neurons that correspond to different positions along the dorsal-to-ventral axis, supporting a model of physiological mechanisms for grid cell responses.

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