Special Reports

Demographic Histories and Patterns of Linkage Disequilibrium in Chinese and Indian Rhesus Macaques

Science  13 Apr 2007:
Vol. 316, Issue 5822, pp. 240-243
DOI: 10.1126/science.1140462

You are currently viewing the abstract.

View Full Text


To understand the demographic history of rhesus macaques (Macaca mulatta) and document the extent of linkage disequilibrium (LD) in the genome, we partially resequenced five Encyclopedia of DNA Elements regions in 9 Chinese and 38 captive-born Indian rhesus macaques. Population genetic analyses of the 1467 single-nucleotide polymorphisms discovered suggest that the two populations separated about 162,000 years ago, with the Chinese population tripling in size since then and the Indian population eventually shrinking by a factor of four. Using coalescent simulations, we confirmed that these inferred demographic events explain a much faster decay of LD in Chinese (r2 ≈ 0.15 at 10 kilobases) versus Indian (r2 ≈ 0.52 at 10 kilobases) macaque populations.

View Full Text

Cited By...