Cell Biology

A Ribbon-Cutting Ceremony

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Science  27 Apr 2007:
Vol. 316, Issue 5824, pp. 517
DOI: 10.1126/science.316.5824.517a

The Golgi complex is a collection of stacked and interconnected membranes found in a juxta-nuclear position in most nucleated animal cells. During cell division, the Golgi complex fragments, presumably to allow for the partitioning of Golgi membranes to both daughter cells, and a protein referred to as BARS (brefeldin A-ADP ribosylated substrate, also known as CtBP1-S) is important in this process. The BARS protein acts to disconnect Golgi stacks from one another, and this fissional step has been shown to be required for successful mitosis. How then can some cells divide without BARS? Colanzi et al. addressed this issue by examining Golgi characteristics in a variety of cell types. They found that fibroblasts from mice genetically deficient in BARS did not possess an interconnected Golgi ribbon, and that BARS activity was not required for the completion of mitosis. On the other hand, in normal fibroblasts, where Golgi stacks were robustly linked, BARS-mediated scission was essential. — SMH

EMBO J. 26, 10.1038/sj.emboj.7601686 (2007).

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