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Regulation of the Germinal Center Response by MicroRNA-155

Science  27 Apr 2007:
Vol. 316, Issue 5824, pp. 604-608
DOI: 10.1126/science.1141229

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Abstract

MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell–dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.

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