Research Article

Regulation of B Versus T Lymphoid Lineage Fate Decision by the Proto-Oncogene LRF

Science  11 May 2007:
Vol. 316, Issue 5826, pp. 860-866
DOI: 10.1126/science.1140881

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Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop into B lineage cells by repressing T cell–instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage.

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