Virology

Shifting Landscapes

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Science  18 May 2007:
Vol. 316, Issue 5827, pp. 957
DOI: 10.1126/science.316.5827.957b

Influenza epidemics are thought to emerge as a result of escape from host immunity as the viral genome mutates along a trajectory of antigenic drift. However, a puzzle for influenza epidemiologists is the limited diversity of observed antigenic types. Recker et al. present a model in which successive antigenic types emerge independently of the mode or tempo of mutation in a cyclical manner. The model is consistent with data from hemagglutination inhibition assays of H3N2. The authors suggest that rather than virus mutation driving the epidemiology of influenza, the changing landscape of host population immunity governs whether and when epidemics emerge. Much of the epidemiology of influenza, such as the re-emergence of an antigenic type, is probably missed in routine clinical data based on detection of symptoms. For instance, data from poultry workers chronically exposed to avian influenza suggest that they enjoy a significant degree of cross-protection against the lethal effects of H5N1. This shift in perspective could have important implications for the way we monitor influenza virus for epidemic prediction and vaccine design. — CA

Proc. Natl. Acad. Sci. U.S.A. 104, 7711 (2007).

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