Technical Comments

Comment on "A Centrosome-Independent Role for γ-TuRC Proteins in the Spindle Assembly Checkpoint"

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Science  18 May 2007:
Vol. 316, Issue 5827, pp. 982
DOI: 10.1126/science.1139484

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Abstract

Müller et al. (Reports, 27 October 2006, p. 654) showed that inhibition of the γ-tubulin ring complex (γ-TuRC) activates the spindle assembly checkpoint (SAC), which led them to suggest that γ-TuRC proteins play molecular roles in SAC activation. Because γ-TuRC inhibition leads to pleiotropic spindle defects, which are well known to activate kinetochore-derived checkpoint signaling, we believe that this conclusion is premature.

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