Technical Comments

Comment on "A Centrosome-Independent Role for γ-TuRC Proteins in the Spindle Assembly Checkpoint"

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Science  18 May 2007:
Vol. 316, Issue 5827, pp. 982
DOI: 10.1126/science.1139523

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Müller et al. (Reports, 27 October 2006, p. 654) proposed a role for microtubule nucleation in mitotic checkpoint signaling. However, their observations of spindle defects and mitotic delay after depletion of γ-tubulin ring complex (γ-TuRC) components are fully consistent with activation of the established pathway of checkpoint signaling in response to incomplete or unstable interactions between kinetochores of mitotic chromosomes and spindle microtubules.

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